منابع مشابه
Phosphoinositide Binding Domains Embracing 3-Phosphate
additional phosphoinositides were found in eukaryotic cells, PtdIns-5-P and PtdIns-3,5-P2 (Dove et al., 1997; Rameh et al., 1997; Whiteford et al., 1997). David A. Fruman, Lucia E. Rameh, and Lewis C. Cantley* Department of Cell Biology The recent identification of proteins that specifically Harvard Medical School bind to lipid products of PI3K allows us to explain the Boston, Massachusetts 021...
متن کاملPhoxy Lipids Revealing PX Domains as Phosphoinositide Binding Modules
and functional insights into the PX domain as a novel The coordination of cellular signaling events requires phosphoinositide binding module. both spatial and temporal regulation. A recurring theme PX Domains as Regulators of Membrane among eukaryotic organisms is the use of phosphoinosiand Protein Trafficking tide-specific binding domains to direct proteins to disThe mechanisms underlying memb...
متن کاملChimeric receptors composed of phosphoinositide 3-kinase domains and FCgamma receptor ligand-binding domains mediate phagocytosis in COS fibroblasts.
Receptors for the Fc portion of IgG (FcgammaR) initiate phagocytosis of IgG-opsonized particles by a process involving the assembly of a multi-molecular signaling complex. Several members of this complex have been identified, including Src family kinases, Syk/ZAP 70 family kinases, and phosphoinositide 3-kinase (PI3-K). To test directly the role of PI3-K in mediating phagocytosis, we assessed t...
متن کاملPrediction of phosphoinositide binding sites
Phosphoinositides (PIs) are a class of phospholipids that are involved in cellular signaling, organelle identity and membrane trafficking. We have applied structural bioinformatics techniques in an attempt to predict the affinity and specificity of protein structures for phosphoinositide compounds. The ability to predict whether a protein is able to recognize phosphoinositide compounds would fo...
متن کاملModular phosphoinositide-binding domains – their role in signalling and membrane trafficking
The membrane phospholipid phosphatidylinositol is the precursor of a family of lipid second-messengers, known as phosphoinositides, which differ in the phosphorylation status of their inositol group. A major advance in understanding phosphoinositide signalling has been the identification of a number of highly conserved modular protein domains whose function appears to be to bind various phospho...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80792-8